During the last few years, the resolution available to interrogate the genomes by means of techniques like next-generation sequencing, genotyping, transcriptomics, proteomics, etc., has undergone an amazing increase.   However, the subsequent conventional single-marker approaches used to...

Sun-exposed human skin contains an extensive number of phenotypicallyintact cell compartments bearing missenseand nonsense mutations in the p53 tumor suppressor gene.   Deep sequencing of sun-exposed and shielded microdissectedskin from mid-life individuals revealed that persistent p53...