The Spatial Genomics Team at CNAG is at the forefront of understanding how gene expression is spatially regulated at the tissue level, aiming to accelerate discoveries and advance treatments.

Our mission is to establish Spatial Transcriptomics and other Spatial Tissue Profiling techniques as standard tools for next-generation pathology, harnessing the prognostic value of tissue resections and biopsies.

Understanding the spatial organization of biological structures is paramount, considering its direct impact on cellular function. Preserving tissue architecture and single-cell resolution, Spatial Omics provides a comprehensive view of cellular and molecular interactions, aiding in the creation of spatially resolved, single-cell maps of health and disease and highlighting the natural link between Spatial Genomics and Single Cell Genomics.

Our interdisciplinary team merges computational, genomics, immunology, biotechnology, and machine learning expertise to help interpret complex spatial data, rapidly advancing our understanding of how the tissue microenvironment influences cell phenotypes / states, and how spatial localization influences disease heterogeneity and outcome. The team strives to identify diagnostic markers, targets for prevention and intervention, and predictive biomarkers for immunotherapy response, eventually contributing to the diagnosis and treatment of complex diseases like cancer, chronic inflammation, infections, and autoimmunity.

Equipped with state-of-the-art spatial omics platforms, including next-generation sequencing and imaging-based techniques, we are committed to continuous innovation, aiming to establish CNAG as a reference for Spatial Omics in Spain.

Anna Pascual

Spatial Genomics Team Leader
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