The GENPIR Project tries to reveal the recent history of the populations of the Catalan Pyrenees, studying the genetic material of its inhabitants. This geographical area has been an important transit area in historical times, which could have left distinctive signs in the genetic composition of...
Coordinator: Oscar Lao (CNAG-CRG), Joan Fibla (UdL) and Pedro Moral (UB)
Parameterisation of large scale cancer models for personalised therapy of triple negative breast cancer
The development of computational models to predict drug response and enhance understanding of cancer onset and progression based on an individual’s molecular profile, is providing new opportunities for personalised medicine in oncology. Computational models based on ordinary differential equations...
Coordinator: Hans Lehrach (MPI MolGen, Germany)
HPC/Exascale Centre of Excellence on Personalised Medicine
Personalised Medicine (PerMed) opens unexplored frontiers to treat diseases at the individual level combining clinical and omics information. However, the performances of the current simulation software are still insufficient to tackle medical problems such as tumour evolution or patient-specific...
Coordinator: Alfonso Valencia (BSC, Spain)
Certain neurological disorders, such as Dravet's syndrome, are complex to treat because they exhibit high rates of drug resistance and have a high variability among patients. To find the most effective treatment, it is often necessary to try different combinations of drugs with each patient, a...
Coordinator: Sandra Acosta, IBE UPF-CSIC, Spain
Beyond One Million Genomes
The project’s purpose is to support the implementation of the declaration of cooperation ‘Towards access to at least 1 million sequenced genomes in the EU by 2022', known as the 1+...
Coordinator: Serena Scollen (ELIXIR) and Ruben Kok (DTL, The Netherlands)
The HCA Pancreas Initiative
The Human Cell Atlas (HCA) is a global initiative with the mission to create comprehensive reference maps of all human cells – the fundamental units of life – as a basis for both understanding human health and diagnosing, monitoring, and treating disease.
Three prior HCA early pilot studies of the...
Coordinator: Roland Eils (Charité Universitätsmedizin Berlin – Berlin Institute of Health, Germany)