Decision on Combinatorial Therapies in Immune-Mediated diseases using Systems approaches

DocTIS is a multicentric project involving diverse basic, applied and clinical research centres from Spain, Sweden, Italy, Germany, UK and USA aimed at improving treatment efficacy in six Immune-Mediated Inflammatory Diseases (IMIDs), encompassing: Crohn’s disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis and psoriatic arthritis. Through the generation of high volumes of data using of modern high-throughput technologies on samples from well-characterized IMID patients, and the use of advanced systems biology analytical approaches, we aim to identify therapeutic combinations that are much more efficacious and safer than current single-drug approaches.

For this ambitious medical research projects eight partners will be collaborating for five years towards this objective. The DocTIS project will integrate different experts from the clinical, biological, computational, and epidemiological areas. These experts will collaborate to generate and analyze high throughput data generated from IMID patients as well as animal models of the disease in order to identify new drug combinations that are highly efficacious.

Within DocTIS, the CNAG-CRG's Single Cell Team will be in charge of generating single-cell and bulk molecular data from biological samples from selected patients.

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Sara Marsal (VHIR, Spain)