CNAG – The Institute

The Centro Nacional de Análisis Genómico (CNAG) is one of the largest Genome Sequencing Centers in Europe.

The CNAG Consortium aims to carry out large-scale projects in DNA/RNA analysis for the improvement of quality of life in collaboration with the Spanish, European and International Research Community. CNAG researchers participate in major International Genome Initiatives such as the Human Cell Atlas (HCA), the International Cancer Genome Consortium (ICGC), the International Human Epigenome Consortium (IHEC), the International Rare Diseases Research Consortium (IRDiRC), the European Reference Genome Atlas (ERGA) and the European Infrastructure for life-science information (ELIXIR), as well as in several EU-funded projects.

CNAG occupies approximately 1,400 square meters of laboratory and office space and operates 4 Illumina instruments (3 NovaSeq6000 and 1 MiSeq) and 2 large Oxford Nanopore Technologies sequencers (1 PromethION 24 and 1 GridION Mk1) that produce more than 7 Tbases of sequencing data per day. The sequencing operation is supported by an extensive informatics infrastructure: 15 petabyte of data storage, 10.000 computing cores and an internal 56 Gb/s network. The operation is certified ISO 9001 and accredited ISO 17025 and serves to deliver standardized, high-quality data for research and clinics. CNAG has highly developed single-cell operation equipped with a 10x Chromium X, 10x Chromium Connect, MissionBio Tapetri for individual cell analyses and for tissue analysis a Nanostring CosMx, 10x Visium and Stereo-seq.

The CNAG has more than 100 professionals, structured in different units such Bioinformatics, Sequencing, Single-cell, Research and Corporate Management.

The Role

The candidate will be integrated in the Single Cell Genomics Team, a highly collaborative, international work environment with well-experienced colleagues in single-cell and spatial data production and analysis. She/he will be involved in the development, implementation and execution of single-cell and spatial sequencing applications. The candidate will be responsible to coordinate large-scale single-cell and spatial project production, including sample biobanking, data generation and documentation. She/he will also be involved in collaborative efforts with our research and clinical partners and diverse production studies of healthy and diseased human/mouse tissues. We are looking for a highly motivated and creative thinking individual who is interested in working in an environment where the technical sophistication of single-cell and spatial analysis meets innovative approaches for interpreting data and generating new knowledge. We encourage and prioritize applications from under-represented minority groups.

The Single Cell Genomics Team at the CNAG-CRG is dedicated to advance genome research of single cells. The mission of the group is the implementation of latest single-cell and spatial sequencing technologies and their application in a research and translational contexts.

The group focuses on the systematic integration of transcriptional and epigenetic data from individual cells to elucidate causalities underlying phenotype formation in health and disease. We successfully established protocols to quantify gene expression and open chromatin of hundred-thousands of isolated single cells (10x Chromium X, 10x Chromium Connect, MissioBio Tapetri, etc) or in tissues (Nanostring CosMx, BGI Stereo-seq, 10x Visium). Our newly developed computational pipelines include methods to deconvolute tissue composition and to track transcriptional dynamics. Our international team joins computational, technical and biological knowledge in order to promote creative thinking while establishing best practices in single-cell and spatial research. The group combines collaborative research, development activities and follows research lines on the generation of human cell atlases and immuno-oncology. We are member of the Human Cell Atlas Project and the LifeTime Initiative.

Whom would we like to hire?

• Trained in next-generation sequencing library preparation.
• More than 5 years of experience as laboratory technician or similar.
• Experience with large-scale project coordination.
• Expertise in single-cell or/and spatial genomics techniques (preferred).
• Good problem solving, organizational and time management skills.
• Strong commitment to high-quality work and sound administrative abilities.

Specific tasks:

• Execution and coordinating of large-scale data generation.
• Testing and implementation of novel single-cell and spatial technologies.
• Automation of single-cell production processes.
 

The Offer

• Contract duration: 3 years
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
• Target start date: 01/11/2023

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.

We are committed to reconcile a work and family life for our employees and are offering the opportunity to benefit from annual leave and flexible working hours.

Application Procedure

All applications must include:

• A complete CV including contact details.
• Contact details of two referees.

All applications must be addressed to Dr. Holger Heyn – holger.heyn@cnag.eu / mireya.fernandez@cnag.eu

Deadline: Please submit your application by 17/11/2023

Interview: Shortlisted candidates will be invited for interview at CNAG on 20/11/2023

Please, see all of our job opportunities in the Career site of CNAG website: https://www.cnag.eu/jobs